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Comparison between intranasal dexmedetomidine and intranasal midazolam as premedication for brain magnetic resonance imaging in pediatric patients: A. Intranasal dexmedetomidine has been used an effective and safe alternative premedication to oral midazolam in children. At a dose of 2micrograms/kg. Background Intranasal dexmedetomidine, a well-tolerated and convenient treatment option, has been shown to induce a favorable.

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Intranasal Dexmedetomidine as a Sedative for Pediatric Procedural Sedation

intranaasl Please review our privacy policy. Intranasal application is a relatively noninvasive, convenient, and easy route of administration and results in a faster onset of action as well as reduces first-pass metabolism.

To avoid bias, observers and attending anesthesiologists were blinded to the study drug. Abstract Background and Aims: Methods This was a prospective observational study, performed in our procedural suite, located at a tertiary medical center.

In this prospective, randomized, double-blind study, we compared intranasal midazolam 0. The dexmedetoimdine age and weight were 2. Comparison of the nasal and sublingual routes.

Related to that we have found it ineffective for kids more than kg… have you found the same? Our secondary objective was to evaluate the safety intrsnasal of IN DEX compared to well-established intravenous sedative medications i. Baseline saturation SpO 2 and heart rate HR were monitored using a pulse oximeter. There are an increasing number of published reports describing the use of DEX; however, there is little agreement regarding the dose and route of administration.


Intranasal Dexmedetomidine

Further Study All of this is anecdotal and should be studied further. It is thought provoking and makes me consider using it in older children as ddxmedetomidine.

In conclusion, IN DEX is effective in providing adequate procedural sedation when used for non-invasive pediatric procedural sedation. Both cohorts were obtained from the same database, using the same recruitment process and similar inclusion criteria.

Limitations of this study include: This can present a problem for very busy sedation services that require rapid patient turnover time. Results The demographic profile was comparable between the two groups [ Table 1 ]. Minimal change in heart rate and blood pressure were noted.

Optimal timing for the administration of intranasal dexmedetomidine for premedication in children.

The total number of subjects undergoing sedation without Dexmedehomidine for similar procedures was males and females. A comparative evaluation of intranasal dexmedetomidine and intranasal midazolam for premedication in children: Sedation was considered successful when the patients were calm and sedated, were not crying and agitated, and allowed dexmedetpmidine induction.

The median and mean sedation scores were lower in Group D 3 and 3. Subjects 6 months to 18 years of age undergoing non-invasive elective procedures were included.


Dexmedetomidine has a much shorter half life than clonidine hours vs. The plan of care was then formulated and discussed with the family. Premedication with midazolam in young children: Phillips, Thank you for this interesting blog.

Intranasal Dexmedetomidine as a Sedative for Pediatric Procedural Sedation

Sedation of infants and children outside of the operating room. This pharmacokinetic profile can facilitate brief periods of deep sedation often needed for imaging procedures in pediatric sedation. A randomized study of intranasal vs.

It gives us as providers another option besides chloral hydrate or placing an IV for medications dxmedetomidine seems to be a little more predictable. Dexmedetomidine for pediatric sedation for computed tomography imaging studies.

On the basis of this information, we have used intranasal dexmedetomidine as a premedication in a number of patients.

The level of sedation and vital signs were documented every 3 to 5 minutes. Your email address will not be published. J Dexmedetomixine Med Res.