PDF Download


Introduction. Lymphangitis carcinomatosa describes a condition of diffuse infiltration of the lymphatics of both the lungs by malignant cells. Pulmonary lymphangitic carcinomatosis (PLC) is a metastatic lung disease characterised by the diffuse infiltration and obstruction of the pulmonary parenchymal. The malignant pulmonary embolization syndromes, pulmonary tumor emboli and lymphangitic carcinomatosis, are associated with a poor.

Author: Baktilar Meztit
Country: Anguilla
Language: English (Spanish)
Genre: Software
Published (Last): 19 August 2008
Pages: 435
PDF File Size: 15.85 Mb
ePub File Size: 5.69 Mb
ISBN: 162-8-54876-237-9
Downloads: 94830
Price: Free* [*Free Regsitration Required]
Uploader: Arashijora

In this article we review the clinical presentation and the diagnostic methods. Lymphangitis carcinomatosa is a term introduced by Troisier in to describe diffuse infiltration of the lymphatics of both the lungs by malignant cells.

Lymphangitis Carcinomatosa: Report of a Case and Review of Literature

Thickening of the bronchovascular interstitium is usually irregular and nodular, lymphajgitis changes seen extending towards the hilum 4. As she was not responding to antibacterial therapy, empirical antifungal and anti viral drugs were added. A computerized tomography CT scan of the lymphangltis and pelvis revealed thickening of the distal stomach with peri-gastric nodes. Spread into the lymphatics in most cases except in bronchogenic adenocarcinoma usually occurs following haematogenous seeding of the lungs, with subsequent lymphatic involvement 1,3.

A high index of suspicion is required to diagnose this condition. J R Coll Surg Edinb. Lymphangitis carcinomatosa may be caused by the following malignancies as suggested by the mnemonic: Mist therapy reconsidered, an evaluation of the respiratory deposition of labeled water aerosols produced by jet and ultrasonic nebulizer.

Support Center Support Center. Lymphangitis Carcinomatosa, Nebulization Chemotherapy How to cite this article: The other theory states that there may be diffuse retrograde permeation and embolization of lymphatics after involvement of the hilar lymph nodes [ 2 ]. The first states that there is haematogenous metastasis producing obliterative endarteritis and then tumor cells subsequently egress through vascular walls into the perivascular lymphatics.


The combination may give a characteristic ” dot in box ” appearance.

Lymphangitis Carcinomatosa: Report of a Case and Review of Literature

Loading Stack – 0 images remaining. Ramkumar S, Fernandes DJ. Lymphangitis carcinomatosa may precede or obscure or dominate any local symptoms and present as a diagnostic problem in dyspnoea. Pathology of the lung, 3 d ed.

Received Carcinoomatosa 9; Accepted Jan Related articles Lymphangitis Carcinomatosa Nebulization Chemotherapy. Author information Article notes Copyright and License information Disclaimer.

The condition affects males more than the females Lymphangitis carcinomatosa is a rare clinico-pathological entity. By using this site, you agree to the Terms of Use and Privacy Policy. Both the peripheral lymphatics coursing in the interlobular septa and beneath the pleura, and the central lymphatics coursing in the bronchovascular interstitium are involved 2.

Principles and practice of hospital medicine: There are currently no effective strategies to treat lymphangitis carcinomatosa. How to cite this URL: Prognosis of patients with lymphangitic carcinomatosis is poor, with approximately half of patients succumbing to their illness within a year of diagnosis 2,3.

Computed lymphangiis and magnetic resonance of the thorax. Carcinomatosz examination revealed her to be in ECOG performance status 2, with an ill defined lump palpable in the epigastrium. However steroid administration may produce symptomatic improvement mainly by alleviating breathlessness [ 1 cracinomatosa.

Lymphangitis carcinomatosa may show the presence of Kerley B lines on chest X-ray. Check for errors and try again. Ramakrishnan Ayloor Seshadri, Phone: Articles Cases Courses Quiz.


The sputum examination did not reveal acid fast bacilli. In most cases, lymphangitis carcinomatosis is caused by the dissemination of ljmphangitis tumor with its cells along the lymphatics.

Lymphangitis carcinomatosa

This article has been cited by other articles in PMC. Breast, lung, stomach, pancreas, and prostate cancers are the most common tumors that result in lymphangitis. Distribution of changes is variable, but most are asymmetric and patchy 3.

Peri-epithelial and lymphatic tumor emboli were also seen. J R Coll Surg Edinb. Some patients experience dyspnoea and abnormal pulmonary function tests early lymphngitis the course of the disease, well before any radiographic abnormalities are evident, whereas others remain asymptomatic until much later 4.

In most cases, lymphangitic carcinomatosis progresses rapidly and patients carcinonatosa see treatment and prognosis belowhowever in some cases changes may remain stable over considerable time 3. Support Radiopaedia and see fewer ads.

Nodular shadows are most commonly seen but diffuse shadows, hilar lymphadenopathy and pleural effusion are additional findings [ 4 ]. Case 4 Case 4. Diagnosis of diffuse malignant infiltration of lung Lymphangitis carcinomatosis by percutaneous fine-needle aspiration biopsy. This results in a prominent definition of the secondary pulmonary lobules, manifesting as tessellating polygons.

Chest radiographs revealed diffuse haziness in both lower lung fields but there was no evidence of pleural effusion or pulmonary metastatic nodules.